Study: Fewer Embryo Transfers and More Cycles Won’t Negatively Affect Delivery Rates

8 week fetusNew research from Belgium has recently found that government policies can restrict the number of egg transfers during an in vitro fertilization cycle and increase the number of cycles allowed without having to worry about a negative impact on the overall delivery rates. In fact, the new study found that doing so would only prove to benefit mothers, babies, health care providers, health insurance companies and government-funded health insurance programs.

Experts have been recommending that only one or two eggs be transferred during in vitro fertilization for some time now. This is because multiple egg transfers increases the chances of delivering high order multiple babies. This can have a negative impact on the mother and babies. It also has a negative impact on health care professionals and health insurance companies (government-funded or otherwise) because of the increased labor and costs of caring for often premature, high risk infants. But by only transferring only one or two embryos, mothers would only give birth to one or two infants (except in rare cases, like embryo splitting). The risk to mother and baby are much lower, as are the costs of care.

Some have been a bit hesitant to implement restrictions on the number of embryos transferred, partly because they are concerned about lower success rates for mothers, but also because they are concerned that fewer embryos would mean more treatments, which could have negatively impacted the costs for government health insurance. However, the recent study, published in Europe’s leading reproductive medicine journal, Human Reproduction, has found exactly the opposite to be true.

Though there have been other studies on the effect of pregnancy and delivery rates of single-embryo transfer policies (particularly in Sweden), this is the first to calculate the cumulative delivery rate for six full cycles.

“Our study is the first to calculate the cumulative delivery rate in a real-life scenario for up to six cycles or 36 months over a period of three years before and after the implementation of the Belgian legislation limiting the number of embryos transferred,” Dr. Karen Peeraer, adjunct head of clinic at Leuven University Fertility Center, Leuven, Belgium, lead researchers of the study, told Science Daily. “It shows that ART can be made reimbursement to an embryo transfer policy with the aim of maintaining high delivery rate and reducing multiple pregnancy rates, the main complication of ART treatment.”

Researchers investigated the delivery rates for three years before and after Belgium a policy that restricted the number of embryos that could be transferred in a single IVF cycle. Before the policy, which was implemented in 2003, a maximum of two or three embryos were transferred. After the legislation, the policy would pay for six treatments of IVF, but only if the number of embryos transferred were relative to the women’s age.

For women under the age of 36, only one embryo would be transferred during the first cycle, regardless of embryo quality. In the second cycle, one embryo would be transferred, but two could be transferred if both were of poor quality. In the next four cycles, a maximum of two embryos could be transferred. In patients between 36 and 39, a maximum of two embryos could be transferred in the first two cycles, and a maximum of three could be transferred in the next four cycles. In patients 40 or older, no legal implications were made, but generally only two to three embryos were transferred.

The study authors looked at a total of 463 patients treated at the Leuven University Fertility Center between July 1, 1999 and June 30, 2002 (prior to the policy) and 795 patients treated at the center between July 1, 2003 and June 30, 2006 (after the policy) and compared their delivery rates. All of the women were younger than 43, and they were followed until after six ART treatments had been completed, until they gave birth, for 36 months, or until they discontinued treatment – whichever came first.

Researchers looked at realistic, optimistic and pessimistic scenarios. In the realistic scenario, they included information on the quality of embryos transferred. This gave them a more accurate prognosis for the patients.

Overall, researchers found that the policy did not have a significant impact on the probability of a woman giving birth to a healthy baby (or twins) or the cumulative delivery rate (CDR) over the course of treatment, the researchers found. In fact, the CDR remained relatively steady – 60.8% after the policy was implemented and 65.6% prior to the policy. However, multiple birth rates were halved as a result of the new legislation – twin delivery rates dropped from 24% to 12%. However, the CDR for the first two cycles was lower after 2003 than before 2003.

“The results of our paper have implications for public health policies worldwide with respect to quality, safety, regulation and financial control of treatments with ART. From a public health point of view the ‘Belgian model’ can now be considered by other governments for application worldwide,” Peeraer said. “We found that among women treated after July 2003, there was a higher proportion of single embryo transfer cycles, a higher singleton delivery rate and a lower twin delivery rate (12% versus 24%) compared to women treated before that date.”

What’s more, Peeraer and her colleagues say that the benefits of using the Belgina model can extend further than just in countries where ART is paid for by the government; even countries like the United States, where patients must pay for their own treatments, can reap benefits from this ART plan. In fact, the researchers are so confident in their statement that they’re going to do additional research to prove their theory.

“In countries without ART reimbursement, the Belgian model with restricted embryo transfer policy can be used to achieve at least a 50% reduction in MPR [multiple pregnancy rates] and associated public health costs, with no negative impact on the CDR per patient, quite relevant to patients who have to pay ART treatments themselves. The substantial amount of money saved by this policy can be used ideally to improve patient access to ART by selective reimbursement,” Peeraer said.

“Our next step is to perform a health-economic analysis to show that the reduction in multiple pregnancy rates results does indeed result in a financial benefit for the government, so that the refunding of six cycles is still a responsible policy,” Professor Thomas D’Hooghe, last author of the paper and head of the Leuven University Fertility Center, told Science Daily. “We hope that this study, together with the results from Sweden, will convince other governments to couple ART reimbursement to strict embryo transfer policies.”

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Kate Givans is a wife and a mother of five—four sons (one with autism) and a daughter. She’s an advocate for breastfeeding, women’s rights, against domestic violence, and equality for all. When not writing—be it creating her next romance novel or here on Growing Your Baby—Kate can be found discussing humanitarian issues, animal rights, eco-awareness, food, parenting, and her favorite books and shows on Twitter or Facebook. Laundry is the bane of her existence, but armed with a cup of coffee, she sometimes she gets it done. Find out more about Kate’s books at

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